Cardioprotective effect of Vitex negundo on isoproterenol-induced myocardial necrosis in wistar rats: A dual approach study

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• 作者：E. Maruthi Prasad^a ; ^{emaruthip@gmail.com} ; Ramgopal Mopuri^b ; Md. Shahidul Islam^b ; Lakshmi Devi Kodidhela^a ;
• 关键词：CVD ; cardiovascular disease ; ISO ; isoproterenol ; FR ; free radicals ; IL-1β ; interleukin-1β ; MI ; myocardial infarction ; ROS ; reactive oxygen species ; NF-κB ; nuclear factor&ndash ; κB ; PAK1 ; p21 activated kinase 1
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：601-610
• 全文大小：2058 K
• 卷排序：85

文摘

Cardiovascular diseases (CVDs) are becoming the major cause of deaths worldwide, and their treatment demands novel therapeutic strategies. In this connection, we have identified p21 activated kinase 1 (PAK1) as a novel therapeutic target for the treatment of myocardial infarction (MI), where its expression is decreased when MI is induced with isoproterenol (ISO), which was brought back normal with pretreatment of Vitex negundo leaf ethanolic extract (VNE). These results were also supported by histopathological studies, cardiac markers, antioxidants, and inflammatory cytokines (NF-κB and IL-1β). Further studies with GC–MS analysis of VNE and in silico experiments confirmed 5,7-dihydroxy-6,4′,-dimethoxy flavonone and 3′,5-dihydroxy-6,7,4′,-trimethoxyflavone are responsible for either maintaining or inducing the expression of PAK1 to protect from MI. Our findings for the first time revealed the use of phytoconstituents in the treatment of MI.