- 作者：M.L. Berg ; U. Idrees ; R. Ding ; S.A. Nesbit ; H.K. Liang ; M.L. McCarthy
- 关键词：Buprenorphine ; Opiate withdrawal ; Opioid withdrawal ; Heroin ; Emergency department ; Prescription opioids
- 刊名：Drug and Alcohol Dependence
- 出版年：2007
- 出版时间：12 January 2007
- 年：2007
- 卷：86
- 期：2-3
- 页码：239-244
- 全文大小：131 K
To examine the use of buprenorphine for the treatment of opioid withdrawal (OW) in an emergency department (ED) setting.
Methods
The medical records of all adult patients who presented to the study ED during a 10 week period for OW were abstracted. Subjects were categorized as receiving buprenorphine, symptomatic treatment or no pharmacologic treatment for their OW. The three groups were compared by patient and service characteristics, withdrawal symptoms and outcomes.
Results
Of the 11,019 patients who presented to the ED during the 10 week study period, 158 (1.4 % ) were eligible. Subjects were more likely to receive buprenorphine (56 % ) compared to symptomatic treatment only (26 % ) or no pharmacologic treatment (18 % ). Subjects who received buprenorphine were more likely to have a history of suicide ideation (34 % versus 12 % p < 0.05) compared to subjects who received symptomatic treatment(s) and were less likely to present with a gastrointestinal complaint (9 % versus 25 % p < 0.05). Subjects who received buprenorphine were less likely to return to the same ED within 30 days for a drug-related visit (8 % ) compared to those who received symptomatic treatment (17 % ) (p < 0.05).
Conclusions
Buprenorphine was a common treatment for OW in this ED without any documented adverse outcomes. Given that it did not result in an increase in drug-related return ED visits and its proven efficacy in other settings, a prospective evaluation of its potential value to ED patients who present with OW is warranted.