Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats
Intra-LC glutamate microinjection induces the expression of opiate withdrawal-like behaviors. SB-334867 did not affect glutamate-induced withdrawal-like signs during the rest phase. SB-334867 attenuated glutamate-induced withdrawal-like signs during the active phase.