Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome

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• 作者：Kara S. Hughan ; MD¹ ; ² ; Hala Tfayli ; MD³ ; Julia G. Warren-Ulanch ; MD⁴ ; Emma Barinas-Mitchell ; PhD⁵ ; Silva A. Arslanian ; MD¹ ; ² ; ^{Silva.Arslanian@chp.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BMI ; Body mass index ; cIMT ; Carotid intima-media thickness ; CRP ; C-reactive protein ; CV ; Cardiovascular ; CVD ; Cardiovascular disease ; HbA1c ; Hemoglobin A1c ; HDL ; High-density lipoprotein ; HOMA ; Homeostatic model assessment ; hsCRP ; High-sensitivity C-reactive protein ; ICAM-1 ; Intercellular adhesion molecule-1 ; IR ; Insulin resistance ; LDL ; Low-density lipoprotein ; NW-non-PCOS ; Normal-weight girls without PCOS ; OB-non-PCOS ; Obese girls without PCOS ; OB-PCOS ; Obese girls with PCOS ; OCP ; Oral contrac
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：168
• 期：Complete
• 页码：104-111.e1
• 全文大小：684 K

文摘

Because in obese youth, pulse wave velocity (PWV), an early cardiovascular disease marker, is elevated, we tested if obese girls with polycystic ovary syndrome (OB-PCOS) have higher PWV and carotid intima-media thickness (cIMT) compared with obese girls without PCOS (OB-non-PCOS) and normal-weight girls without PCOS (NW-non-PCOS) and whether PWV and cIMT correlate with inflammatory and circulating endothelial function biomarkers.

Study design

Cross-sectional study of PWV and cIMT in 91 OB-PCOS, 30 obese controls (OB-non-PCOS), and 19 normal-weight controls (NW-non-PCOS). Body composition, blood pressure, fasting glucose, insulin, lipid concentrations, and endothelial function biomarkers were measured. OB-non-PCOS and OB-PCOS underwent 2-hour oral glucose tolerance testing.

Results

PWV was higher in OB-PCOS (664 ± 24 cm/s) and OB-non-PCOS (624 ± 37 cm/s) compared with NW-non-PCOS (468 ± 13 cm/s, P < .001), with no differences in cIMT. Systolic blood pressure, low-density lipoprotein, and non-high-density lipoprotein cholesterol were higher, and high-density lipoprotein cholesterol and indices of insulin sensitivity were lower in OB-PCOS and OB-non-PCOS compared with NW-non-PCOS. Vascular cell adhesion molecule-1 and high-sensitivity C-reactive protein were higher in OB-PCOS compared with NW-non-PCOS. PWV correlated with adiposity (r_s = .46), insulin sensitivity index (homeostatic model assessment-insulin resistance r_s = .31), systolic blood pressure (r_s = .24; P ≤ .003 for all), and free testosterone (r_s = .24; P = .03). In multiple regression analysis with PWV as the dependent variable and age, race, body mass index, PCOS, and dysglycemia as independent variables, only body mass index was an independent contributor to the model (r² = 0.068, P = .003).

Conclusions

In adolescent girls, obesity and not PCOS appears to be associated with heightened cardiovascular disease risk. Increased PWV, vascular cell adhesion molecule-1, and high-sensitivity C-reactive protein may be the earliest subclinical atherosclerosis biomarkers in OB-PCOS.