- 作者：Lourdes Ibá ; ñ ; ez ; Abel Lopez-Bermejo ; Marta Diaz ; Francis de Zegher
- 关键词：Fetal growth ; adiposity ; bone maturation ; abdominal fat ; visceral fat ; body composition ; insulin ; IGF-I ; high-molecular-weight adiponectin ; leptin ; DHEAS ; SHBG ; LDL cholesterol ; HDL cholesterol ; polycystic ovary syndrome ; PCOS
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：July 2011
- 年：2011
- 卷：96
- 期：1
- 页码：220-223
- 全文大小：156 K
Objective
To study across childhood the features of small for gestational age (SGA) girls with spontaneous catch-up growth.Design
Longitudinal study (age 2–8 years).
Setting
University hospital.
Patient(s)
Post-catch-up SGA girls (n = 18) versus healthy control girls born appropriate for gestational age (AGA; n = 13).
Intervention(s)
None.
Main Outcome Measure(s)
Height, weight, fasting glucose, insulin, IGF-I, high-molecular-weight (HMW) adiponectin, LDL and HDL cholesterol, triglycerides, body composition by absorptiometry (2–8 years); visceral fat by magnetic resonance imaging (6–8 years); bone age (by automated reading), sex hormone–binding globulin, DHEAS, and leptin (8 years).
Result(s)
At age 2 years, AGA and SGA girls were comparable for all study markers. Between 2 and 8 years, girls were prepubertal; AGA and SGA girls gained height, lean mass, and bone mineral content similarly; other outcomes diverged so that, at age 8, SGA girls had markedly higher levels of circulating insulin, IGF-I, DHEAS, LDL cholesterol, and leptin; lower HMW adiponectin and SHBG levels; more total and visceral fat (without being obese); and an older bone age.
Conclusion(s)
After completing catch-up growth and before starting puberty, SGA girls develop an ensemble that includes not only central adiposity, hyperinsulinemia, and hypoadiponectinemia but also hyperleptinemia, dyslipidemia, lower SHBG and higher DHEAS levels, and faster bone maturation.