Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities
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- 作者：Jorge Franco1 ; Uthra Balaji1 ; Elizaveta Freinkman3 ; Agnieszka K. Witkiewicz1 ; 2 ; agnes.witkiewicz@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Erik S. Knudsen1 ; 2 ; erik.knudsen@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：14
- 期：5
- 页码：979-990
- 全文大小：4498 K
文摘
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CDK4/6 inhibition increases oxidative phosphorylation through the RB pathway
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Compensatory activation of MTOR occurs downstream of CDK4/6 inhibition
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Combination treatments have disparate effects on cellular metabolism
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Therapeutically targeting select features of CDK4/6 arrested cells is feasible