A systematic review of randomized controlled trials of prenatal and postnatal vitamin A supplementation of HIV-infected women

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• 作者：Eugene Justine Kongnyuy ; Charles Shey Wiysonge ; Muki Shehu Shey
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：104
• 期：1
• 页码：5-8
• 全文大小：248 K

文摘

We searched the Cochrane Library, MEDLINE, EMBASE, AIDSearch, and Gateway to assess the effect of prenatal and/or postnatal vitamin A supplementation on the risk of mother-to-child transmission (MTCT) of HIV and other pregnancy outcomes. We included 5 trials totaling 7528 women (4 trials of prenatal and 1 trial of postnatal supplementation). Overall, there was no evidence of an effect of prenatal and/or postnatal vitamin A supplementation on the risk of MTCT of HIV (Relative Risk [RR] 1.06, 95 % Confidence Interval [CI] 0.89–1.26). However, prenatal vitamin A supplementation significantly improved birth weight (weighted mean difference 89.78; 95 % CI, 84.73–94.83), but there was no evidence of an effect on stillbirths (RR 0.99; 95 % CI, 0.68–1.43), preterm births (RR 0.88; 95 % CI, 0.65–1.19), death before 24 months among live births (RR 1.08; 95 % CI, 0.91–1.29), and maternal death (RR 0.83; 95 % CI, 0.59–1.17). The available evidence does not support vitamin A supplementation of HIV-infected pregnant and lactating women, despite improvement in birth weight.