Surface development of molecularly imprinted polymer films to enhance sensing signals

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• 作者：Piyush Sindhu Sharma ; Marcin Dabrowski ; Francis D¡¯Souza ; Wlodzimierz Kutner
• 关键词：AEP ; [(p-acryloylaminophenyl)-{4(aminophenyl)-diethyl ammonium}-ethylphosphonate] ; AFM ; atomic force microscopy ; APBA ; aminophenylboronic acid ; ATRP ; atom-transfer radical polymerization ; BPE2+ ; bis-N-methylpyridinium-4 ; 4&rsquo ; -ethylene ; BSA ; bovine seru
• 刊名：TrAC Trends in Analytical Chemistry
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：51
• 期：Complete
• 页码：146-157
• 全文大小：1832 K

文摘

Molecular imprinting of polymers is a well-established procedure for preparing artificial recognition units of chemical sensors. This procedure can produce materials of selectivity comparable to that of their biological counterparts. Deposition of a thin film of a molecularly imprinted polymer (MIP), playing a role of recognition unit, directly on surface of the transduction unit integrates these units to result in a chemical sensor. However, a smooth and continuous thin film of such a unit limits sensitivity of the devised chemosensor because of slow diffusion of an analyte through the film towards less accessible imprinted molecular cavities in the film bulk on the one hand and a low specific surface area on the other. Therefore, this area should be increased in a controllable way by developing the film surface. For that, macroporous MIP with large surface area, deposited directly on a transducer surface, effectively enhance signals in sensing applications. This review describes in detail a growing trend to prepare MIPs with a high (surface area)-to-volume ratio to enhance the sensing signal.