Somatic mutation profiling of follicular thyroid cancer by next generation sequencing
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- 作者：Michal Swierniaka ; b ; Aleksandra Pfeifera ; c ; Tomasz Stokowya ; d ; Dagmara Rusineka ; Mykola Chekane ; Dariusz Langee ; Jolanta Krajewskaa ; Małgorzata Oczko-Wojciechowskaa ; Agnieszka Czarnieckaf ; Michal Jarzabg ; Barbara Jarzaba ; Bartosz Wojtasa ; h ; bwojtas@io.gliwice.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Somatic mutation ; Next generation sequencing ; Follicular thyroid cancer
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：433
- 期：Complete
- 页码：130-137
- 全文大小：944 K
文摘
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The spectrum of somatic alterations in follicular thyroid tumors is largely unknown.
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Cancer genes in 82 thyroid tissue samples were tested by next generation sequencing.
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Single nucleotide variants were most common; large structural changes were rare.
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New somatic alterations were found in genes as well as non-coding regions.
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Distinct tumor somatic alterations suggested previously unreported heterogeneity.