Novel androgen-induced activity of an antimicrobial β-defensin: Regulation of Wolffian duct morphogenesis

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• 作者：Camilla M. Ribeiro^a ; Lucas G.A. Ferreira^a ; Daniel S. Thimoteo^a ; Lee B. Smith^b ; Barry T. Hinton^c ; Maria Christina W. Avellar^a ; ^{avellar@unifesp.br}
• 关键词：Wolffian duct ; Male infertility ; Androgen ; Epididymis ; β-defensin ; Innate immunity
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：142-152
• 全文大小：3089 K
• 卷排序：442

文摘

SPAG11C immunoreactivity is exclusively found in the Wolffian duct mesenchyme. Androgen receptor signaling regulates SPAG11C expression in developing Wolffian duct. Recombinant hSPAG11C protein affects Wolffian duct morphogenesis ex vivo. The hSPAG11C mechanism relies on regulation of ductal epithelial cell proliferation. The β-defensin SPAG11C is suggested as a new player in Wolffian duct morphogenesis.