Synthesis of the first unnatural schisantherins and their effects in multidrug-resistant cancer cells
详细信息 查看全文
- 作者：Rainer Schobert ; Werner Kern ; Wolfgang Milius ; Tamara Ackermann ; Miroslava Zoldakova
- 关键词：Schisandra chinensis ; Esterification ; Phosphorus ylides ; Microwave ; Multidrug resistance
- 刊名：Tetrahedron Letters
- 出版年：2008
- 出版时间：19 May 2008
- 年：2008
- 卷：49
- 期：21
- 页码：3359-3362
- 全文大小：164 K
文摘
Schisandrol A, a dibenzocyclooctadiene lignan, was obtained by a simplified procedure from Schisandra chinensis fruits. Its reaction with carboxylic acids to give new esters (schisantherins) required special conditions such as microwave irradiation. An X-ray single crystal structure analysis of schisandrol A revealed a sterical shielding of the secondary OH group as the likely reason. The cinnamoate inhibited the P-gp drug transporters of multidrug-resistant human Kb-V1 cervix carcinoma cells better than the natural benzoate and comparable to the clinical sensitizer verapamil.