Distinct Pores for Peroxisomal Import of PTS1 and PTS2 Proteins
详细信息 查看全文
- 作者：Malayko Montilla-Martinez1 ; 5 ; Sabrina Beck2 ; 5 ; Jessica Klü ; mper2 ; 5 ; Michael Meinecke3 ; Wolfgang Schliebs2 ; Richard Wagner1 ; 4 ; ri.wagner@jacobs-university.de" class="auth_mail" title="E-mail the corresponding author ; Ralf Erdmann2 ; ralf.erdmann@rub.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：13
- 期：10
- 页码：2126-2134
- 全文大小：2471 K
文摘
- •
Import of folded proteins into peroxisomes requires distinct PTS-specific pores
- •
PTS2 pore is formed by the cytosolic co-receptor Pex18 and docking complex Pex14/Pex17
- •
The PTS2 receptor is not part of the unloaded pore
- •
Complex gating of the PTS2 channel is voltage and cargo dependent