Epigenetic Classification of Human Mesenchymal Stromal Cells
详细信息 查看全文
- 作者：Danilo Candido de Almeida1 ; 2 ; 3 ; Marcelo R.P. Ferreira4 ; 5 ; Julia Franzen1 ; 2 ; Carola I. Weidner1 ; 2 ; Joana Frobel1 ; 2 ; Martin Zenke2 ; 6 ; Ivan G. Costa4 ; Wolfgang Wagner1 ; 2 ; wwagner@ukaachen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：epigenetic score ; mesenchymal stromal cell ; mesenchymal stem cell ; fibroblast ; bone marrow ; adipose tissue ; DNA methylation
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：6
- 期：2
- 页码：168-175
- 全文大小：2549 K
文摘
- •
Mesenchymal stromal cells and fibroblasts have different DNA methylation patterns
- •
A two-CpG signature can distinguish between MSCs and fibroblasts
- •
Another two-CpG signature can discern MSCs from bone marrow and adipose tissue
- •
Subclones of MSCs are correctly classified by these epigenetic scores