Successful Treatment of Patients With Multiple Myeloma and Impaired Renal Function With Lenalidomide: Results of 4 German Centers

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• 作者：Katharina Oehrlein¹ ; ^{Katharina.Oehrlein@med.uni-tuebingen.de} ; Christian Langer² ; Isrid Sturm³ ; Wolfram Pö ; nisch⁴ ; Corinna Hahn-Ast⁵ ; Sigrid Kuhn⁶ ; Katja C. Weisel¹
• 关键词：Creatinine clearance ; Lenalidomide ; Multiple myeloma ; Relapse ; Renal impairment
• 刊名：Clinical Lymphoma Myeloma and Leukemia
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：12
• 期：3
• 页码：191-196
• 全文大小：296 K

文摘

Purpose

Renal impairment is one of the main complications of multiple myeloma associated with unfavorable prognosis. Lenalidomide in combination with dexamethasone is an effective treatment of relapsed and/or refractory multiple myeloma and may be used in patients with myeloma and with renal insufficiency with appropriate dose adaption according to creatinine clearance (CLCr). However, there are limited data on the use of this regimen in patients with myeloma and with impaired renal function.

Patients and Methods

We report on 26 patients, in 4 German centers, with impaired renal function and relapsed and/or refractory multiple myeloma who were treated with lenalidomide/dexamethasone-based regimens; we retrospectively analyzed their data.

Results

All 26 patients had a CLCr < 60 mL/min. Six patients were permanently or temporarily dialysis dependent. Overall response rate (ie, at least a partial response) was 84 % . The rate of renal response (at least minor renal response) was 42 % , with 6 patients achieving a complete renal response. A median time of 28 days was documented until first response. Six patients had grade 3/4 thromboembolic events; all but one of these patients received prophylaxis with acetylsalicylic acid.

Conclusion

Lenalidomide-based treatment is highly effective and is an attractive treatment option in patients with multiple myeloma with impaired renal function. In this analysis, renal function was improved in a substantial proportion of patients.