Comparing the role of metabotropic glutamate receptors in long-term potentiation and in learning and memory

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• 作者：Riedel ; Gernot ; Wetzel ; Wolfram ; Reymann ; Klaus G.
• 关键词：Metabotropic glutamate receptors (mGluRs) ; long-term potentiation (LTP) ; hippocampus ; spatial and nonspatial learning ; memory formation
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：1996
• 出版时间：July, 1996
• 年：1996
• 卷：20
• 期：5
• 页码：761-789
• 全文大小：1.61 M

文摘

1. Neuronal plasticity has been suggested to be the physical substrate for changes underlying the expression of memory. One model which has attracted wide attention as a possible candidate of such neuronal plasticity is long-term potentiation (LTP), mainly investigated in the hippocampus of rodents. Moreover, various processes with different time constants may underlie LTP, and these phases show striking correspondence to different phases of memory.