Controlled derivatization of polyhalogenated quinolines utilizing selective cross-coupling reactions

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• 作者：M. Brad Nolt ; Zhijian Zhao ; Scott E. Wolkenberg
• 关键词：Silica nanoparticles ; Ru(bpy)₃²⁺ ; Au nanoparticles ; Layer-by-layer assembly film ; Electrogenerated chemiluminescence
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：5 May 2008
• 年：2008
• 卷：49
• 期：19
• 页码：3137-3141
• 全文大小：124 K

文摘

Straightforward procedures for the derivatization of tri- and tetrahalogenated quinolines utilizing sequential selective Pd-catalyzed cross-coupling reactions are described. Taking advantage of intrinsic halide reactivity, substrate control, and appropriate reaction conditions, highly selective reactions at the quinoline 3-, 4-, and 6-position are possible.