Ethanol-Associated Cardiomyocyte Apoptosis and Left Ventricular Dilation Are Unrelated to Changes in Myocardial Telomere Length in Rats
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- 作者：Andrew R. Raymond ; PhD ; Jason Becker ; BScHons ; Angela J. Woodiwiss ; PhD ; Hendrik L. Booysen ; PhD ; Gavin R. Norton ; MD ; PhD ; Richard L. Brooksbank ; PhD ; richard.brooksbank@wits.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ethanol ; LV dilation ; cardiomyocyte apoptosis ; telomere length
- 刊名：Journal of Cardiac Failure
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：4
- 页码：294-302
- 全文大小：703 K
文摘
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Four months of ethanol administration (5% v/v) to rats resulted in LV dilation.
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LV dilation was associated with increased cardiomyocyte apoptosis.
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Ethanol failed to produce effects on cardiac or leukocyte telomere length.
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Telomere length was not associated with LV dilation or cardiomyocyte apoptosis.
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Ethanol-induced apoptosis and dilation occurs independently from telomere attrition.