Magnetic resonance elastography of uterine leiomyomas: a feasibility study

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• 作者：Elizabeth A. Stewart ; F. Andrei Taran ; Jun Chen ; Bobbie S. Gostout ; David A. Woodrum ; Joel P. Felmlee ; Richard L. Ehman
• 关键词：Leiomyomas ; magnetic resonance ; elasticity ; uterus ; feasibility studies ; elasticity imaging techniques/methods ; adult ; humans ; female
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：95
• 期：1
• 页码：281-284
• 全文大小：396 K

文摘

Objective

To determine the feasibility of performing in vivo magnetic resonance elastography (MRE) for uterine leiomyoma.

Design

Pilot study.

Setting

Academic medical center.

Patient(s)

Six subjects planning surgical excision of uterine leiomyomas.

Intervention(s)

MRE before planned surgery.

Main Outcome Measure(s)

Achieving an appropriate phase signal–to-noise ratio (PSNR) in the leiomyoma to allow assessment of leiomyoma elasticity in kilopascals (kPa).

Result(s)

MRE was successful in all subjects for uteri ranging from 100 to >1,000 g. Subjects had body mass indexes ranging from 23.0 to 38.0 kg/m². Appropriate PSNRs, ranging from 5.45 to 42.28, were achieved for leiomyomas in all subjects. Mean elasticity of uterine leiomyomas ranged from 3.95 to 6.68 kPa.

Conclusion(s)

MRE is a feasible technique for studying the in vivo mechanical properties of uterine leiomyomas and demonstrates significant heterogeneity in elasticity between lesions. Further work is necessary to optimize the technique and understand the clinical utility of this technique for women with uterine leiomyomas.