Zinc protoporphyrin/heme as an indicator of iron status in NICU patients

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• 作者：S ; ra E. Juul ; Joan C. Zerzan ; Thomas P. Str ; jord ; David E. Woodrum
• 刊名：The Journal of Pediatrics
• 出版年：2003
• 出版时间：March 2003
• 年：2003
• 卷：142
• 期：3
• 页码：273-278
• 全文大小：442 K

文摘

Objective Zinc protoporphyrin/heme ratio (ZnPP/H) has been well established as an indicator of functional iron deficiency in subjects 6 months of age to adult. The primary objective of this study was to establish normative values for ZnPP/H in NICU patients and secondarily to explore the utility of this test as an indicator of iron deficiency in neonates. Study design ZnPP/H and complete blood counts were obtained weekly on consecutive NICU patients. Gestational age, growth variables, iron supplementation, erythropoietin treatment, and blood transfusions were documented. Results are reported as mean ± SD. A value of P < .05 was considered significant. Results ZnPP/H ratios (n = 639) were evaluated from 143 infants. During the first week of life, ZnPP/H was inversely correlated with gestational age (n = 78, P < .001, R = −0.72). Maternal diabetes, growth retardation, and exposure to chorioamnionitis were independent risk factors for high ZnPP/H. Both iron supplementation and blood transfusion decreased ZnPP/H (P < .001). Erythropoietin treatment was associated with an increase in reticulocyte count and ZnPP/H (P < .001). Conclusions ZnPP/H is inversely correlated with gestational age, and the range in all newborn infants is higher than in adults. ZnPP/H is elevated in certain infant subpopulations, which suggests that they may require additional iron supplementation. (J Pediatr 2003;142:273-8)