Fundamentals of Neurogastroenterology: Basic Science

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• 作者：Stephen J. Vanner¹ ; ^{vanners@hdh.kari.net" class="auth_mail" title="E-mail the corresponding author} ; Beverley Greenwood-Van Meerveld² ; Gary M. Mawe³ ; Terez Shea-Donohue⁴ ; Elena F. Verdu⁵ ; Jackie Wood⁶ ; David Grundy⁷
• 关键词：Sensory Physiology ; Enteric Nervous System ; Neuroimmune Signaling ; Mucosal Barrier Function
• 刊名：Gastroenterology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：150
• 期：6
• 页码：1280-1291
• 全文大小：1857 K

文摘

This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled Rome IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs, and new areas for future research into their pathophysiology.