De novo protein design: how do we expand into the universe of possible protein structures?
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- 作者：Derek N Woolfson1 ; 2 ; 3 ; d.n.woolfson@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Gail J Bartlett1 ; Antony J Burton1 ; Jack W Heal1 ; Ai Niitsu1 ; Andrew R Thomson1 ; Christopher W Wood1 ; 2
- 刊名：Current Opinion in Structural Biology
- 出版年：2015
- 出版时间：August 2015
- 年：2015
- 卷：33
- 期：Complete
- 页码：16-26
- 全文大小：2277 K
文摘
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The structural space explored by natural proteins is limited.
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This raises questions: what protein folds are possible, and how do we access them?
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Parametric protein-design methods are being developed that could explore these.
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Designing symmetric α-helical bundles and coiled coils is particularly tractable.
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General parametric descriptions for other potential protein folds are needed.