Association study between Van der Woude Syndrome causative gene GRHL3 and nonsyndromic cleft lip with or without cleft palate in a Chinese cohort
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- 作者：Yirui Wanga ; b ; c ; 1 ; Yimin Suna ; b ; c ; d ; 1 ; Yongqing Huange ; f ; g ; 1 ; Yongchu Panh ; 1 ; Zhonglin Jiai ; j ; Lijuan Mae ; f ; Lan Mah ; Feifei Lank ; l ; m ; Yuxi Zhoub ; c ; Jiayu Shin ; Xiong Yange ; f ; Lei Zhangb ; c ; Hongbing Jiangh ; Min Jiangf ; g ; Aihua Yink ; l ; m ; 2 ; yinaiwa@vip.126.com" class="auth_mail" title="E-mail the corresponding author ; Jing Chenga ; b ; c ; 2 ; Lin Wangh ; 2 ; lw603@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yinxue Yange ; f ; g ; 2 ; nyfyyyx@126.com" class="auth_mail" title="E-mail the corresponding author ; Bing Shii ; j ; 2 ; shibingcn@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Gene
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：588
- 期：1
- 页码：69-73
- 全文大小：330 K
文摘
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GRHL3 was identified as VWS causative gene. It may be a candidate gene for NSCL/P.
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Association study of GRHL3 with NSCL/P was performed in a large Chinese cohort.
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Three SNPs, rs10903078, rs4638975 of GRHL3 exceeded the significance threshold.
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A haplotype rs10903078-rs6659209 of GRHL3 exceeded the significance threshold.
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But no SNP or haplotype survived Bonferroni correction for multiple comparisons.