CD8+ Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy
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- 作者：Emily K. Cartwright1 ; Lori Spicer1 ; S. Abigail Smith1 ; David Lee1 ; Randy Fast2 ; Sara Paganini1 ; Benton O. Lawson1 ; Melon Nega1 ; Kirk Easley3 ; Joern E. Schmitz4 ; 6 ; Steven E. Bosinger1 ; Mirko Paiardini1 ; Ann Chahroudi1 ; 5 ; Thomas H. Vanderford1 ; Jacob D. Estes2 ; Jeffrey D. Lifson2 ; Cynthia A. Derdeyn1 ; Guido Silvestri1 ; 7 ; gsilves@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：45
- 期：3
- 页码：656-668
- 全文大小：2615 K
文摘
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CD8+ lymphocyte depletion during ART increases SIV plasma viral load (72- to 350-fold)
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Reconstitution of CD8+ T cells is associated with re-establishment of viral control
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Pre-depletion levels of SIV DNA+ CD4+ T cells correlate with viremia after depletion