Separation of enantiomers of drugs by capillary electrophoresis: Part 8. β-Cyclodextrin as chiral solvating agent

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• 作者：B. Lin ; X. Zhu ; S. Wuerthner ; U. Epperlein ; B. Koppenhoefer
• 刊名：Talanta
• 出版年：1998
• 出版时间：August 1998
• 年：1998
• 卷：46
• 期：4
• 页码：743-749
• 全文大小：124 K

文摘

As part of a comprehensive screening program on the separation of chiral drugs by capillary zone electrophoresis, we have investigated the enantio-separation of 54 drug racemates with β-cyclodextrin as a chiral solvating agent (CSA), thus complementing previous studies on 34 drug racemates. Fourteen out of the 54 analytes investigated have been separated into the enantiomers, yielding an overall success rate of 24.4 % for 86 drug racemates investigated in total.