Tract-based analysis of white matter integrity in psychotic and nonpsychotic bipolar disorder

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• 作者：Andrew Ji^a ; Douglass Godwin^a ; Jerrel Rutlin^b ; Sridhar Kandala^a ; Joshua S. Shimony^b ; Daniel Mamah^a ; ^{mamahd@psychiatry.wustl.edu}
• 关键词：Bipolar disorder ; DTI ; Psychosis ; White matter ; TRACULA
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：209
• 期：Complete
• 页码：124-134
• 全文大小：1517 K
• 卷排序：209

文摘

Psychotic and non-psychotic bipolar disorder may represent dissociable biological subtypes of bipolar disorder. Powerful, automated tract analysis (TRACULA) was utilized to study white matter integrity in bipolar disorder. Decreased fractional anisotropy in psychotic and non-psychotic bipolar disorder was seen compared to healthy controls. Fractional anisotropy of several white-matter tracts correlated with positive and negative symptoms severity.