Les transplantations d'organes en l'an 2000
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- 作者：Wynckel ; Alain ; Cohen ; Jacques-Henri Max
- 关键词：Transplantation - allograft rejection - infection - cancer immunosuppression - immunisation ; Transplantation - rejet de greffe - infection - cancer - immunosuppresseur - immunisation
- 刊名：Revue Francaise des Laboratoires
- 出版年：2000
- 出版时间：November, 2000
- 年：2000
- 卷：2000
- 期：327
- 页码：83-90
- 全文大小：1.01 M
文摘
Optimal therapeutic management in transplantation delivers the least amount of immunosuppressive drugs required to avoid graft rejection since overtreatment could lead to undesirable side effects like malignancies and infections. The development of new immunosuppressive drugs reflects the progress in understanding the molecular mechanism involved in allograft rejection. Each type of transplant has its own type of evolving immunosuppressive strategies. This review presents new aspects of antigen recognition by T lymphocytes, general mechanisms of action and deleterious effects of immunosuppressive drugs. Clinical results obtained in the main organ transplantations are also discussed.