Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules
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- 作者：Matthias D&rsquo ; Hondta ; Evelien Wynendaelea ; Kirsten Vandercruyssena ; Tiene Bautersb ; Johan Vandenbrouckeb ; Steven Mullensc ; Chris Vervaetd ; Jean Paul Remond ; Bart De Spiegeleera ; Bart.DeSpiegeleer@UGent.be" class="auth_mail
- 关键词：Pharmaceutical capsule compounding ; API loss ; Surface profilometry ; Radial distribution function (RDF) ; R-GETAWAY autocorrelation
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：5 August 2014
- 年：2014
- 卷：96
- 期：Complete
- 页码：68-76
- 全文大小：1327 K
文摘
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We investigated API loss during pharmaceutical compounding of capsules using UPLC-PDA.
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Largest API loss was located at mortar surface, followed by pestle and plastic card.
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Roughness (Ra) of mortar surface has significant influence on the API loss.
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The intrinsic chemical properties of the API also influences the overall loss.
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A model was developed to identify capsule preparations with higher risk to API loss.