Reorganization of Enhancer Patterns in Transition from Naive to Primed Pluripotency
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- 作者：Christa Buecker1 ; Rajini Srinivasan1 ; Zhixiang Wu2 ; Eliezer Calo1 ; Dario Acampora3 ; 4 ; Tiago Faial1 ; Antonio Simeone3 ; 4 ; Minjia Tan2 ; Tomasz Swigut1 ; swigut@stanford.edu" class="auth_mail ; Joanna Wysocka1 ; 5 ; wysocka@stanford.edu" class="auth_mail
- 刊名：Cell Stem Cell
- 出版年：5 June 2014
- 年：2014
- 卷：14
- 期：6
- 页码：838-853
- 全文大小：4270 K
文摘
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Oct4 binding and enhancer patterns change in naive to primed pluripotency transition
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Oct4 cooperates with distinct set of transcription factors in naive and primed state
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Ectopic Otx2 can reorganize Oct4 binding even in the absence of differentiation cues
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Otx2 and Oct4 ability to engage new enhancers is dependent on cis-regulatory features