In Vivo Efficacy of CMX001 Against Herpes Simplex Virus Types 1 and 2
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Strategies to prevent neonatal herpes are limited by the failure of currently available diagnostic tests to rapidly detect women in labour who are at risk of transmitting herpes, by the absence of proven antenatal screening tests for HSV, and by transmission of herpes to neonates from asymptomatic mothers. The most useful current strategy is careful examination of the vulva and cervix for herpes lesions in women coming to labour. Caesarean section is indicated in women with clinically apparent genital herpes at delivery. Effective and safe antiviral agents are available for treatment of maternal and neonatal herpes.

le&_coverDate=03 % 2F31 % 2F1993&_sk=999929998&view=c&wchp=dGLbVlW-zSkzS&md5=e56e8cf2d0a1831dcd61f63041d4f7fc&ie=/sdarticle.pdf"">le=""vertical-align:absmiddle;"" border=""0"" src=""http://www.sciencedirect.com/scidirimg/icon_pdf.gif"" alt=""""> Purchase PDF (3422 K)le>
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Antiviral Research
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lt=""You are not entitled to access the full text of this document"" title=""You are not entitled to access the full text of this document"" width=12 height=14""> leURL&_udi=B6T2H-476KWRX-3F&_user=10&_coverDate=12 % 2F31 % 2F1985&_rdoc=1&_fmt=high&_orig=article&_cdi=4919&_sort=v&_docanchor=&view=c&_ct=7836&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d1c7849dee02438d0d206484aa4f173c"">Comparative activities of combinations of acyclovir, vidarabine or its 5′-monophosphate, and cloned human interferons against herpes simplex virus type 2 in human and mouse fibroblast cultures
Antiviral Research, Volume 5, Issue 6, December 1985, Pages 325-333
Lawrence Richard Crane, Debra Ann Milne

Abstract
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le=""line-height:150 % "">Human interferon-αA/D (Bgl), an alpha-hybrid cloned interferon, displays activity in both human and mouse cell lines. We measured the effects of this interferon in double and triple combinations with acyclovir, vidarabine or its 5′-monophosphate against herpes simplex virus type 2 in mouse and human fibroblasts. A 75 % cytopathic effect reduction assay employing a modified checkerboard technique was used. Results in human fibroblasts were compared with those obtained when recombinant human interferonα2 was substituted for the hybrid. Combinations of the hybrid interferon and nucleoside antiviral agents evoked comparable synergistic isobolograms and fractional inhibitory concentration indices in human and mouse cells versus herpes simplex virus type 2. Similar interactions were found when human interferon-α2 was substituted. Uninfected cells treated with the tested combinations showed no toxicity. These data suggest that combinations of recombinant human interferonα-A/D (Bgl) and nucleosides in mouse models of herpes infection deserve study.

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In Vivo Efficacy of CMX001 Against Herpes Simplex Virus Types 1 and 2

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