Indexes of β-cell function from the oral glucose tolerance test can modestly predict pancreatic β-cell area in Korean

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• 作者：Soo Kyoung Kim^a ; ¹ ; Jae Hyeon Kim^a ; ¹ ; Ji Young Park^a ; Hee Sung No^b ; Kee-Taek Jang^c ; Jin Seok Heo^d ; Seong Ho Choi^d ; Dong Wook Choi^d ; Kwang-Won Kim^a ; ^{kw1234@skku.edu"" rel=""nofollow}
• 关键词：&#x3b2 ; -Cell function ; &#x3b2 ; -Cell area ; Oral glucose tolerance test
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：93
• 期：2
• 页码：220-227
• 全文大小：793 K

文摘

Aims

Pancreatic β-cell function indexes have been suggested using the oral glucose tolerance test (OGTT). Here, we investigated whether β-cell function index from the OGTT reflects pancreatic β-cell area in Korean patients.

Methods

The study consisted of 45 patients who underwent pancreatectomies. Before operation, a 75-g OGTT was performed. Immunohistochemical staining was performed, and indexes of β-cell function from the OGTT data were compared with the pancreatic β-cell area.

Results

The β-cell area of the pancreas was 1.07 1; 0.33 % in the normal glucose tolerance group, 1.71 1; 0.85 % in the pre-diabetes group (impaired glucose tolerance and impaired fasting glucose), and 1.08 1; 0.57 % in the diabetes group. The β-cell area of the pre-diabetes group was significantly higher than that of the diabetes group. Pancreatic β-cell area showed a significant correlation with a homeostasis model assessment of β-cell function (r = 0.358, P = 0.016), disposition index (r = 0.336, P = 0.024), fasting glucose (r = "12;0.359, P = 0.015), and the C-peptide/glucose 30 min ratio (r = 0.319, P = 0.035).

Conclusions

Some parameters of β-cell function from the OGTT showed a significant relationship with the β-cell area of pancreas.