Renal Insufficiency and Vascular Complications After Primary Angioplasty Via Femoral Route. Impact of Vascular Closure Devices Use

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• 作者：Oscar Prada-Delgado ; ^{Oscar.Prada.Delgado@sergas.es} ; Rodrigo Esté ; vez-Loureiro ; Ramó ; n Calviñ ; o-Santos ; Eduardo Barge-Caballero ; Jorge Salgado-Ferná ; ndez ; Pablo Piñ ; ó ; n-Esteban ; José ; Manuel Vá ; zquez-Rodr&#237 ; guez ; Guillermo Aldama-Ló ; pez ; Xacobe Flores-R&#237 ; os ; Mar&#237 ; a Rita Soler-Mart&#237 ; n ; Nicolá ; s Vá ; zquez-Gonzá ; lez ; Alfonso Castro-Beiras
• 关键词：CKD ; chronic kidney disease ; MVC ; major vascular complications ; PA ; primary angioplasty ; PCI ; percutaneous coronary intervention ; STEACS ; ST-segment elevation acute coronary syndrome ; VCD ; vascular closure device
• 刊名：Revista Española de Cardiología (English Edition)
• 出版年：2012
• 出版时间：March, 2012
• 年：2012
• 卷：65
• 期：3
• 页码：258-264
• 全文大小：253 K

文摘

Introduction and objectives

We sought to determine the incidence of vascular complications in patients with chronic kidney disease undergoing primary angioplasty via the femoral route; we also evaluated the safety and efficacy of the use of vascular closure devices in this setting.

Methods

Registry of 527 patients undergoing primary angioplasty via the femoral route from January 2003 to December 2008. Chronic kidney disease was defined as creatinine clearance less than 60 mL/min. The primary endpoint was the presence of major vascular complications.

Results

Baseline chronic kidney disease was observed in 166 (31.5 % ) patients. Patients with chronic kidney disease experienced higher rates of major vascular complications compared to those without worsening of renal function (8.4 % vs 4.2 % ; P=.045), especially those requiring transfusion (6.6 % vs 1.9 % ; P=.006). Among patients with chronic kidney disease, 129 (77.7 % ) received a vascular closure device and manual compression was used in 37 patients (22.3 % ). The risk of major vascular complications was significantly lower with vascular closure device use compared to manual compression (4.7 % vs 21.6 % ; P=.003). Multivariable logistic regression analysis showed that the use of a vascular closure device was independently associated with a decreased risk of major vascular complications in patients with chronic kidney disease undergoing primary angioplasty (odds ratio=0.11; 95 % confidence interval, 0.03-0.41; P=.001).

Conclusions

Patients with chronic kidney disease undergoing primary angioplasty via the femoral route experience higher rates of major vascular complications. The use of vascular closure devices in this group of patients is safe and is associated with lower rates of major vascular complications compared to manual compression.