DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1

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• 作者：Juan Huertas-Mart&iacute ; nez^a ; Franck Court^b ; Santiago Rello-Varona^a ; David Herrero-Mart&iacute ; n^a ; Olga Almacellas-Rabaiget^a ; Miguel Sá ; inz-Jaspeado^a ; Silvia Garcia-Monclú ; s^a ; Laura Lagares-Tena^a ; Raquel Buj^c ; Lourdes Hontecillas-Prieto^d ; Ana Sastre^e ; Daniel Azorin^f ; Xavier Sanjuan^a ; ^g ; Roser Ló ; pez-Alemany^a ; Sebastian Moran^b ; Josep Roma^h ; Soledad Gallego^h ; Jaume Moraⁱ ; Xavier Garc&iacute ; a del Muro^a ; ^j ; Paloma H. Giangrande^k ; Miquel A. Peinado^c ; Javier Alonso^l ; Enrique de Alava^d ; ^m ; Dave Monk^b ; Manel Esteller^b ; ⁿ ; ^o ; Oscar M. Tirado^a ; ^{omartinez@idibell.cat}
• 关键词：DNA methylation ; Ewing sarcoma ; PTRF ; Cavin-1 ; Caveolae ; Apoptosis
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：196-207
• 全文大小：4327 K
• 卷排序：386

文摘

Methylation profiling uncovers PTRF/Cavin-1 as a tumor suppressor in ES. Restoration of CAV1 and PTRF by co-expression increases caveolae formation and cell death. Cell death induction is p53-dependent via MDM2 phosphorylation. PTRF re-expression and caveolae restoration could serve as new therapeutic options for ES.