Aging phenotype and its relationship with IGF-I gene promoter polymorphisms in elderly people living in Catalonia

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• 作者：Mireia Mora^a ; Marí ; a José ; Perales^b ; Mateu Serra-Prat^c ; Elisabet Palomera^c ; Xavier Buquet^d ; Josep Oriola^b ; Manel Puig-Domingo^a ; ^e ; ^{mpuigd@gmail.com"" rel=""nofollow} ; The Matar&#xf3 ; Ageing Study Group¹
• 关键词：Ageing ; IGF-I ; Promoter region polymorphisms ; Metabolic syndrome
• 刊名：Growth Hormone IGF Research
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：21
• 期：3
• 页码：174-180
• 全文大小：458 K

文摘

Objectives

Genetic variations in the Insulin/IGF-I genes pathway have been related to longevity, dementia, metabolic diseases and cancer. The purpose of the present study was to investigate the 192 bp allele of IGF-I gene promoter and its relationship with metabolic syndrome (MS) components, mental and nutritional state, muscle strength and functional capacity in an aged Spanish population.

Design

Population-based study (Mataró Ageing Study), including 292 subjects (144 men and 148 women, mean age 77.0 ± 5.4). Anthropometric variables, lipid profile, glucose and blood pressure (BP) were measured; mental state (MMSE), nutritional state (MNA) and Barthel scale were performed, and were correlated to the presence of the 192 bp allele of IGF-1 gene promoter polymorphisms.

Results

MS (ATP-III criteria) was found in 49.5 % (41.4 % in men and 57.6 % in women). The 192 bp allele of IGF-I gene promoter was distributed as: 41.9 % homozygous, 44.3 % heterozygous and 13.9 % were non-carriers of this allele. A lower prevalence of metabolic syndrome was observed in homozygous (41.9 % vs 54.9 % in heterozygous + non-carriers, p = 0.031). Mental state (MMSE), nutritional state (MNA) and Barthel scale were better in homozygous individuals compared to heterozygous and non-carriers (p = 0.015, p = 0.026 and 0.047, respectively). In men, MNA was better in homozygous with no differences in MMSE and Barthel scales. In homozygous women, BP was lower (p = 0.009) and Barthel scale was better (p = 0.05) with no differences in MMSE and MNA.

Conclusion

Homozygosity for the 192 bp allele of the IGF-I gene polymorphism suggests a healthier aging condition, with less prevalence of cardiometabolic disturbances, and better mental, nutritional and functional state.