IRE1α-XBP1 signaling pathway, a potential therapeutic target in multiple myeloma
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- 作者：Lin Chen ; Qian Li ; Tiantian She ; Han Li ; Yuanfang Yue ; Shuang Gao ; Tinghui Yan ; Su Liu ; Jing Ma ; Yafei Wang ; Drwang2005@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple myeloma ; UPR ; IRE1&alpha ; XBP1s ; Therapy ; Prognosis
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：7-12
- 全文大小：882 K
文摘
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ER stress and UPR play a significant role in plasma differentiation and MM.
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10">IRE1α-XBP1 signaling pathway is an important branch of UPR.
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15">XBP1s levels could predict the prognosis of MM.
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XBP1s levels could assess the effect of thalidomide and bortezomib therapy.
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Many targeted drugs develop anti-tumor effect by regulating IRE1α-XBP1 pathway.