Systemic inflammation induces anxiety disorder through CXCL12/CXCR4 pathway
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- 作者：L. Yang1 ; M. Wang1 ; Y.Y. Guo1 ; T. Sun ; Y.J. Li ; Q. Yang ; K. Zhang ; S.B. Liu ; M.G. Zhao ; minggao@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Y.M. Wu ; yumeiwu@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anxiety ; Lipopolysaccharide ; CXCL12 ; CXCR4 ; Glutamate ; Neurotransmission
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：352-362
- 全文大小：3742 K
文摘
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Lipopolysaccharide (LPS) i.p injection induced anxiety-like behaviors in adult mice.
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Mice anxiety-like behaviors induced by LPS was mediated by CXCL12/CXCR4.
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Antagonist and shRNA for CXCR4, ameliorated anxiety behaviors mediated by CXCL12.
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CXCL12/CXCR4 enhanced glutamatergic transmission by increasing sEPSC frequency.