Tongluo Xingnao Effervescent Tablet preserves mitochondrial energy metabolism and attenuates cognition deficits in APPswe/PS1De9 mice
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- 作者：Yuan Daia ; 1 ; daniya5@sina.com" class="auth_mail" title="E-mail the corresponding author ; Tao Mab ; 1 ; matao327@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiangyi Rena ; 1 ; amideby@sina.cn" class="auth_mail" title="E-mail the corresponding author ; Jiangping Weia ; sichuanwjp@163.com" class="auth_mail" title="E-mail the corresponding author ; Wenjun Fua ; fwj10330@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuntong Maa ; mayuntong06@163.com" class="auth_mail" title="E-mail the corresponding author ; Shijun Xua ; docxu@126.com" class="auth_mail" title="E-mail the corresponding author ; Zhanjun Zhangc ; d ; zhang_rzs@bnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer&rsquo ; s disease ; Tongluo Xingnao Effervescent Tablet ; Mitochondria ; Energy metabolism
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：630
- 期：Complete
- 页码：101-108
- 全文大小：1486 K
文摘
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TXET, a traditional Chinese herbal formula, has been widely used for decades in China.
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TXET can ameliorate cognitive dysfunction.
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We investigated the effects of TXET on mitochondrial function and energy metabolism in APPswe/PS1De9 mice.
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TXET increased the mitochondrial membrane potential, energy charge levels, activity of respiratory chain complexes and Na+-K+ ATPase activity in APPswe/PS1De9 mice.