Transcription factor Dlx3 induces aryl hydrocarbon receptor promoter activity
详细信息 查看全文
- 作者：June Ho Shina ; b ; c ; Mikel D. Haggadonea ; b ; c ; John B. Sunwooa ; b ; c ; sunwoo@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Natural killer cells ; Dlx3 ; Aryl hydrocarbon receptor ; Xenobiotic response element ; Transcriptional regulation
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：7
- 期：Complete
- 页码：353-360
- 全文大小：1473 K
文摘
- •
A mechanism describing Dlx3 as a positive regulator of AhR is proposed.
- •
Dlx3 and AhR are robustly co-expressed in human and murine CD127+ NK cells.
- •
Dlx3 induces AhR expression by directly binding the AhR promoter.
- •
Dlx3 activates expression of AhR, which in turn activates Xenobiotic Responsive Elements (XRE).