Human immune-cell response towards diverse xenogeneic and allogeneic decellularized biomaterials

详细信息    查看全文

• 作者：Erwin Rieder^a ; Anneliese Steinacher-Nigisch^b ; Gü ; nter Weigel^c ; ^{guenter.weigel@tirol-kliniken.at}
• 关键词：Biological mesh ; Immune response ; Tissue engineering
• 刊名：International Journal of Surgery
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：36
• 期：part_PA
• 页码：347-351
• 全文大小：1248 K
• 卷排序：36

文摘

A study, using a validated ex-vivo setting, was able to observe diverse species-specific immune response towards different processed biomaterials. Neither effective decellularization nor cross-linking of xenogeneic tissue eliminates human cell-mediated response toward these biological grafts. The absence of cell response demonstrated in human dermal or vascular material, is likely predictive for a less exaggerated immune reaction in vivo.