Cerebrovascular pathology during the progression of experimental Alzheimer's disease
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- 作者：Patrizia Giannonia ; b ; c ; Margarita Arango-Lievanoa ; b ; c ; Ines Das Nevesa ; b ; c ; Marie-Claude Rousseta ; b ; c ; Ké ; vin Barangerd ; Santiago Riverad ; Freddy Jeanneteaua ; b ; c ; Sylvie Claeysena ; b ; c ; sylvie.claeysen@igf.cnrs.fr" class="auth_mail" title="E-mail the corresponding author ; Nicola Marchia ; b ; c ; nicola.marchi@igf.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAA ; Microvascular inflammation ; Alzheimer ; 5xFAD
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：107-117
- 全文大小：3373 K
文摘
5xFAD mice show CAA on leptomeningeal and penetrating vessels.
Parenchymal microvascular damage paralleled plaque formation in fronto-parietal cortices, later affecting the hippocampus.
Inflammatory IBA1/GFAP reactivity topographically overlapped with microdomains of vascular damage and parenchymal plaques.
Microvascular inflammatory changes in 5xFAD mice were multicellular, accompanied by PDGFRβ+ pericytes loss and rearrangement overtime.