Cognitive benefits of memantine in Alzheimer's 5XFAD model mice decline during advanced disease stages
详细信息 查看全文
- 作者：Latha Devia ; Masuo Ohnoa ; b ; mohno@nki.rfmh.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Memantine ; 5XFAD ; Learning and memory ; Fear conditioning ; Spontaneous alternation ; Aβ oligomers
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：60-66
- 全文大小：567 K
文摘
Subchronic high-dose memantine impairs memory performances in wild-type control mice.
Subchronic memantine improves memory impairments in 5XFAD mice at 6–7 months of age.
Cognitive benefits of memantine in 5XFAD mice are independent of Aβ reductions.
Memantine cannot rescue more profound memory deficits in 5XFAD mice at advanced age.