Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels

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• 作者：Erkan Buyuk ; David B. Seifer ; Joshua Younger ; Richard V. Grazi ; Harry Lieman
• 关键词：Anti-M&#xfc ; llerian hormone ; ART ; M&#xfc ; llerian inhibiting substance ; diminished ovarian reserve ; elevated FSH levels ; ovarian response
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：95
• 期：7
• 页码：2369-2372
• 全文大小：149 K

文摘

Objective

To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels.

Design

Retrospective study.

Setting

Academic and academically affiliated assisted reproductive technology (ART) programs.

Patient(s)

Seventy-three women undergoing ART with elevated early follicular FSH levels.

Intervention(s)

None.

Main Outcome Measure(s)

Number of oocytes retrieved during ART cycle, number of day 3 embryos, and cycle cancellation and clinical pregnancy rates.

Result(s)

Random AMH levels were strongly correlated with the number of oocytes retrieved during an ART cycle among women with elevated FSH (r = 0.55). Women with elevated FSH who had a random serum AMH level of 0.6 ng/mL or higher had twice the number of oocytes retrieved (11 ± 1.3 vs. 5.6 ± 0.6), a greater number of day 3 embryos (5.7 ± 0.9 vs. 3 ± 0.5), and approximately a third of the cycle cancellation rate (14 % vs. 41 % ) compared with women with a random serum AMH below 0.6 ng/mL. The clinical pregnancy rate was also higher among women with a random serum AMH ≥0.6 ng/mL (28 % vs. 14 % ), however, the difference was not statistically significant.

Conclusion(s)

A random serum AMH level is useful in setting expectations for ART prognosis in women with elevated early follicular-phase serum FSH levels.