刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:February 2017
年:2017
卷:1861
期:2
页码:68-78
全文大小:1752 K
卷排序:1861
文摘
A molecular mode of action of Connexin43 mimetic peptide (Peptide5) is proposed. Peptide5 blocks Connexin43 hemichannel-mediated ATP release. Peptide5 acts on the extracellular loop two of Connexin43. Peptide5 sequence specificity is required for hemichannel block. The SRPTEKT motif is central to Peptide5 mechanism.