Fullerene inhibits benzo(a)pyrene Efflux from Cyprinus carpio hepatocytes by affecting cell membrane fluidity and P-glycoprotein expression
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- 作者：Qiqing Chena ; b ; Xialin Hua ; b ; Rui Wanga ; b ; Jin Yuana ; b ; Daqiang Yina ; b ; yindq@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：P-Glycoprotein ; Efflux ability ; Fullerene ; Cell membrane ; Cyprinus carpio ; Benzo(a)pyrene
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：174
- 期：Complete
- 页码：36-45
- 全文大小：1969 K
文摘
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nC60 is a potent P-glycoprotein inhibitor for pumping out benzo(a)pyrene.
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Humic acid can alleviate the nC60 damage.
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nC60 increases the membrane fluidity of hepatocytes.
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nC60 down-regulates P-glycoprotein’s mRNA and protein expression.