Pancreatic KATP channel structure is determined at 5.6-Å resolution by cryo-EM TMD0-L0 fragment mediates the interactions between Kir6.2 and SUR1 An allosteric inhibitor bound to SUR1 stabilizes Kir6.2 in a closed conformation PIP2 uncouples Kir6.2 from glibenclamide-bound SUR1