KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis
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- 作者：Daoyan Wei1 ; Liang Wang1 ; Yongmin Yan1 ; Zhiliang Jia1 ; Mihai Gagea2 ; Zhiwei Li1 ; Xiangsheng Zuo3 ; Xiangyu Kong1 ; Suyun Huang4 ; Keping Xie1 ; 5 ; kepxie@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：29
- 期：3
- 页码：324-338
- 全文大小：9135 K
文摘
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KLF4 induces ductal but represses acinar identity in pancreatic acinar cells
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KLF4 is required for acinar-to-ductal cell reprogramming
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Mutant KRas, injury, and stress signaling converge to activate KLF4 expression
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KLF4 synergizes with mutant KRas in initiation of PanIN