Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption
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- 作者：Susu Zhang1 ; Hongquan Dong1 ; Xiang Zhang ; Nana Li ; Jie Sun ; dgsunjie@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Yanning Qian ; yanning_qian@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：POCD ; postoperative cognitive dysfunction ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; ECs ; endothelial cells ; TJs ; endothelial cells ; MMP ; matrix metalloproteinase ; ECM ; extra cellular matrix ; EB ; Evans blue ; TB ; toluidine blue ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：298
- 期：part_PB
- 页码：158-166
- 全文大小：3344 K
文摘
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Activated mast cells are involved in neuroinflammation and cognitive dysfunction following surgery by promoting BBB disruption.
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Mast cell stabilizer disodium cromoglycate alleviated surgery-induced cognitive decline and neuroinflammation.
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Disodium cromoglycate inhibited the increase of BBB permeability induced by surgery.