Signal transducer and activator of transcription 5B (STAT5B) modulates adipocyte differentiation via MOF
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- 作者：Peng Gaoa ; gaopengts@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuchao Zhanga ; b ; yc.zhang@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Yuantao Liuc ; sduliuyuantao@163.com" class="auth_mail" title="E-mail the corresponding author ; Jicui Chena ; chenjc1988@126.com" class="auth_mail" title="E-mail the corresponding author ; Chen Zonga ; zongchen1203@163.com" class="auth_mail" title="E-mail the corresponding author ; Cong Yua ; yc-1127@163.com" class="auth_mail" title="E-mail the corresponding author ; Shang Cuia ; csup123@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Weina Gaoa ; weinana0398@163.com" class="auth_mail" title="E-mail the corresponding author ; Dandan Qina ; 18364135491@163.com" class="auth_mail" title="E-mail the corresponding author ; Wenchuan Sund ; sunwenchuan111@163.com" class="auth_mail" title="E-mail the corresponding author ; Xia Lia ; lixia1666@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiangdong Wanga ; e ; xdongw@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：C/EBPα ; CCAAT/enhancer-binding protein α ; ChIP ; chromatin immunoprecipitation ; Fabp4 ; fatty acid-binding protein 4 ; HFD ; high fat diet ; MOF ; Males absent on the first ; PPARγ ; peroxisome proliferator-activated receptor γ ; STAT5B ; signal transducer and activator of transcription 5B ; KD ; knock-down
- 刊名：Cellular Signalling
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：27
- 期：12
- 页码：2434-2443
- 全文大小：1613 K
文摘
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Knocking-down either STAT5B or MOF can promote adipocyte differentiation in 3 T3-L1 preadipocytes.
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STAT5B modulates MOF expression by binding to its promoter.
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Over-expression MOF inhibits C/EBPα promoter trans-activation.
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STAT5B negatively modulates adipogenesis via regulating MOF.
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STAT5B and MOF is negative regulator of adipocyte differentiation.