MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence
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- 作者：Hongping Xiaa ; b ; xiahp82@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shik Nie Konga ; kong.shik.nie@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author ; Jianxiang Chena ; chen.jian.xiang@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author ; Ming Shic ; ShiMing@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Karthik Sekara ; sekar.karthik@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author ; Veerabrahma Pratap Seshachalama ; seshachalam.veerabrahma.pratap@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author ; Muthukumar Rajasekarana ; muthukumar.rajasekaran@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author ; Brian Kim Poh Gohd ; brian.goh@sgh.com.sg" class="auth_mail" title="E-mail the corresponding author ; London Lucien Ooid ; e ; dsoopj@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author ; Kam M. Huia ; b ; f ; g ; cmrhkm@nccs.com.sg" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oncogenic kinase ; MELK ; Hepatocellular carcinoma ; Recurrence ; FOXM1
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：85-93
- 全文大小：2852 K
文摘
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MELK is overexpressed in HCC and correlates with early recurrence and survival.
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Silencing MELK inhibits growth, invasion, stemness and tumorigenicity of HCC cells.
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MELK regulates cell cycle progression and mitosis-related genes through targeting FOXM1.