Association between physical activity and inflammatory bowel disease risk: A meta-analysis

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• 作者：Qiang Wang¹ ; Ke-Qun Xu¹ ; Xiang-Rong Qin¹ ; Wen-Lu ; Yan-Liu ; Xiao-Yong Wang ; ^{wxy20009@126.com}
• 关键词：Crohn's disease ; Inflammatory bowel disease ; Meta-analysis ; Physical activity ; Ulcerative colitis
• 刊名：Digestive and Liver Disease
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：48
• 期：12
• 页码：1425-1431
• 全文大小：900 K
• 卷排序：48

文摘

Previous studies of an association between physical activity and inflammatory bowel disease have yielded conflicting results.AimThis meta-analysis was conducted to clarify whether there is an association between physical activity and inflammatory bowel disease.MethodsThe PubMed and Web of Science databases were searched for relevant studies published up to October 2015. Data were extracted and the summary relative risks (RRs) were calculated using a random effects or a fixed-effects model, according to heterogeneity.ResultsSeven studies were included in the analysis. Relative to individuals with low physical activity, those who participated in high physical activity had an RR of 0.63 (95% CI, 0.50–0.79) for developing Crohn's disease. In stratified analyses, a significantly lower risk for Crohn's disease was associated with high physical activity in Europeans only (RR, 0.62; 95% CI, 0.43–0.91); population-based control studies (RR, 0.56; 95% CI, 0.41–0.76); and case-control studies (RR, 0.56; 95% CI, 0.41–0.75). The data of 6 studies were pooled to analyze the effect of physical activity on the risk of ulcerative colitis, and no significant association was found (RR, 0.82; 95% CI, 0.68–1.00).ConclusionsThe pooled results of observational studies support that physical activity has a protective effect against Crohn's disease.