A truncated IL-12rβ1 receptor ameliorates chronic graft-versus-host disease-induced lupus nephritis by inhibiting Th1 and Th17 cells
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- 作者：Chen Wang ; Wei Guo ; Di Cai ; Xin Wang ; Dongmei Yu ; Xiangdong Gao ; xdgao@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wenbing Yao ; wbyao@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-17 ; IL-23R ; Lupus nephritis ; Chronic graft-versus host disease
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：544-551
- 全文大小：878 K
文摘
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We report a soluble receptor, tIL12rβ1 for the treatment of lupus nephritis.
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We present a new therapeutic strategy targeting IL-12/IL-23 p40 for lupus nephritis.
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Both Th1 and Th17 cells are involved in the pathogenesis of cGVHD-induced SLE.